鸡蛋摄入量与罹患心血管疾病、糖尿病风险的荟萃分析

【中】Li Y,Zhou C,Zhou X,Li L

【编者导读】北京阜外心血管病医院,心血管病国家重点实验室,针对涉及32万人的14个研究项目进行了荟萃分析(Meta分析),分析结果表明:高鸡蛋摄入将提高罹患心血管疾病、糖尿病以及糖尿病患者心血管疾病的风险。

 

摘要

目的

为评估鸡蛋摄入量与罹患心血管疾病(cardiovascular diseases,CVD)和糖尿病是否存在量效关系(dose-response relationship)。

方法

我们系统地检索了截止2012年12月的MEDLINE数据库文献。采用固定效应模型(fixed- effects model)或随机效应模型(random-effects model)计算相对风险(relative risks,RRs)以及95%置信区间(confidence intervals,CIs)。利用亚组分析(Subgroup analyses)探索异质性的潜在因素。利用加权线性回归模型(weighted linear regression model)估算量效关系。

结果

本研究包括14个研究项目的320,778名研究对象。鸡蛋摄入量最高以及最低的受试者罹患心血管疾病(CVD),未合并糖尿病的心血管疾病、糖尿病相对风险分别是:1.19(95%置信区间为:1.02~1.38)、1.83(95%置信区间为:1.42~2.37)和1.68(95%置信区间为:1.41~2.00)。每周每多摄入4个鸡蛋者,则罹患心血管疾病、未合并糖尿病的心血管疾病、糖尿病的相对风险分别为:1.06(95%置信区间为:1.03~1.10),1.40(95%置信区间为:1.25~1.57),1.29(95%置信区间为:1.21~1.37)。亚组分析结果显示:相对美国人群,其他欧美国家的人群罹患心血管疾病风险提高(相对危险为2.00,95%置信区间1.14~3.51:1.13,95%置信区间为0.98~1.30,亚组差异P=0.02)

(编者注:文中相对风险是指:一个群体暴露在一定风险下与未暴露在该风险下某事件发生概率的比值。RR大于或小于1,表示暴露因素对疾病有影响,当其大于1时,表示暴露因素是疾病的有害因素,且RR越大,暴露因素对疾病的影响就越大。)

结论

我们的研究结果表明鸡蛋的摄入量与罹患心血管疾病和糖尿病之间存在正相关量效关系。

关键词

心血管疾病,糖尿病,鸡蛋,荟萃分析

来源:北京阜外心血管病医院,国家心血管病中心,心血管病国家重点实验室

发表于2013年8月《动脉粥样硬化》杂志

229(2):524-30. doi: 10.1016/j.atherosclerosis.2013.04.003.

PMID:23643053

翻译:悠悠步行者

http://www.ncbi.nlm.nih.gov/pubmed/23643053

Atherosclerosis 2013 Aug;229(2):524-30. doi: 10.1016/j.atherosclerosis.2013.04.003. Epub 2013 Apr 17.

Egg consumption and risk of cardiovascular diseases and diabetes: a meta-analysis.

Li Y,Zhou C,Zhou X,Li L

Source

State Key Laboratory of Cardiovascular Medicine, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.

Abstract

OBJECTIVES:

To assess the dose-response relationship between egg consumption and the risk of cardiovascular diseases (CVD) and diabetes.

METHODS:

We systematically searched MEDLINE database through December 2012. Fixed- or random-effects model was used to pool the relative risks (RRs) and their 95% confidence intervals (CIs). Subgroup analyses was performed to explore the potential sources of heterogeneity. Weighted linear regression model was used to estimate the dose-response relationship.

RESULTS:

Fourteen studies involving 320,778 subjects were included. The pooled RRs of the risk of CVD, CVD for separated diabetes patients, and diabetes for the highest vs lowest egg intake were 1.19 (95% CI 1.02-1.38), 1.83 (95% CI 1.42-2.37), 1.68 (95% CI 1.41-2.00), respectively. For each 4/week increment in egg intake, the RRs of the risk for CVD, CVD for separated diabetes patients, diabetes was 1.06 (95% CI 1.03-1.10), 1.40 (95% CI 1.25-1.57), 1.29 (95% CI 1.21-1.37), respectively. Subgroup analyses showed that population in other western countries have increased CVD than ones in USA (RR 2.00, 95% CI 1.14 to 3.51 vs 1.13, 95% CI 0.98 to 1.30, P = 0.02 for subgroup difference).

CONCLUSIONS:

Our study suggests that there is a dose-response positive association between egg consumption and the risk of CVD and diabetes.

Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

KEYWORDS:

Cardiovascular disease, Diabetes, Egg, Meta-analysis

PMID:23643053